Good point about all of the variables that comprise the characteristics of an engine and timing. Just for a little background here are a few engines that we have tuned and some rough timing numbers they use. Blown alcohol 377ci small block chevy mechanical injected (roots type blower because it does make a difference to inlet ait temp) that makes 1000 HP 36-40 degrees of timing depending on altitude, air, and how agressive tune needs to be (not very agressive right now 20% underdriven had to detune to run a nostalga class, this is where we found this motor will not run on less than 34 degrees of timing @ 5000+ feet elevation went to 600 feet then we could make it run at 32 degrees), target AF of 10.1:1 gas scale and roughly 4.4:1 on methanol scale, 480ci blown alcohol big block chevy EFI 2200 HP(Procharger, much more efficient than the roots = less heat and less fuel 10.7:1 on gas scale roughly 4.68:1 on the methanol scale 34-36 degrees of timing, Honda 2.3L Turbo EFI 1018 HP(pent roof 4 valve head mentioned earlier and the small bore, 33-34 degrees of timing, GM 3.98L (our own custom 4.2L out of the Trail Blazer and Envoy, Procharger compounded into twin 76mm turbos EFI, BTW we are sponsored by Procharger and Garrett on this one, again the 4 valve head with a 3.5" bore) 2000+ HP cant be specific on the horsepower numbers lots of people watching this one, timing is 33-36 degrees. These ranges are conservative sometimes higher but we hardly ever go lower EGT's go through the roof, it is like bentwings1 said will you pay the price of the parts to win a round???
So I understand what is being said about all of these variables. Brobards is not that far off on fuel at 9.5:1 gas scale or .65 lambda or 4.2 methanol(nobody has mentioned intercooling this plays a big role in heat in the combustion chamber and overall fuel consumption even with methanol), if anything once he brings the timing up he is going to find himself on the fat side of things if he stays with these numbers, air-fuel changes with timing(if you haven't ever used wideband maybe you haven't seen this but it does). The Toyota 2JZ 3.0L motor will not run on 6 degrees of total timing turbocharged with methanol(maybe on the two step for antilag), if you think this info is inaccurate call Titan Motorsports in Florida they hold the world record with the Toyota 2JZ turbocharged on methanol see what they think about 6 degrees of timing. Get yourself some EGT probes so you can see what the timing is doing to your temps, bring it up into the thirties on timing, dyno it there and you'll find the sweet spot, and if you are going to run 40+ lbs of boost get yourself some o-rings and copper head gaskets it will make your life much easier.:-D