There are so many approaches to it but lets look at 2 of them:
1-proportion your foundation members such as the floor beams, the footing(strip or pad)etc. so that the bearing pressure is within 2500 psf. If you keep within this limit, the settlement should be with that allowed. You can calculate that using the standard foundation settlement equation. If it falls outside that recommended, then apply a safety factor of about 1.5-2.0 and re-proportion your footing.
2-Use the finite element modelling soft ware for foundation modelling to model your foundation(if you do not know of any good one, post again and ask me of one),then go further to check if the settlement calculated from the model is within that allowed for your structure. Check with the codes to be sure that you are obeying the norms as stipulated.
Good luck.
Teddy