Basically it comes down to this, how many pounds/hour or mass rate do you want to flow and what pressure drop do you want. The density or gravity adjusts from standard to flowing conditions and the K (Cp/Cv) adjusts for, molecule size and distance between molecules the speed of sound which places an upper limit on the system.
Generally, if the pressure drop required increases, the port area needed to pass a fixed mass will decrease or at a fixed port opening, an increase in pressure drop will allow more mass to pass through it. However, if the pressure drop through the valve is more than 50% of the inlet pressure, then for a fixed port area, more pressure drop will not allow any more mass to to pass through the valve.