If you dump all cold air in one end, and return the other, one problem will be to find a diffuser and grille large enough. the other problem is, where th diffuser is, it will be really cold and gradually it will get warmer as the air picks up heat.
Maybe people can move their desk based on how cold or hot they like it?
What most offices would do is to have multiple diffuser in areas where you expect people to spend a lot of time (i.e. desks). and place return grilles at locations that don't have a lot of cooling load (those just get cooled by the average room temp air).
You don't want return (low pressure) too close to diffusers (high pressure) since the air would just go the path of least resistance and wouldn't detour through the people.
It is a bit of an art with science. I recommend reading up on some Price and other manufacturer literature for VAV systems etc.