"A couple of issues which didn't seem to be addressed previously were EtOH's air/fuel ratio, flame front speed, and also NOX emissions of higher compression engines."
Stoichiometric AFR of neat EtOH: 9.0. For blends, you can find out the StAFR by determining the mass fraction of each fuel component and its corresponding StAFR. NOTE: Mass fraction is not the same as volume fraction, by means of which fuels are usually blended. Laminar burning speed is faster than gasoline (look up if you want exact values). NOx emission is ambiguous because of additional variables like charge cooling.
Several posts back tried to calculate the heat of compression using isentropic relations. The value of the specific heat ratio (kappa) used was wrong. For pure air, it's about 1.4. In a fuel-air mixture, that value is lower. 1.3 can be used as an approximation for stoichiometric mixtures of most hydrocarbon fuels and air for engines that are not direct injected. So in the equation (T2/T1)=(v1/v2)^(k-1) the value in the exponent should be around 0.3, not 5/2. Within any reasonable effective (dynamic) compression ratio used, autoignition is not an issue.
Next, it must be said that it is a very common mistake to conclude compression ratio in a piston engine as a ratio of pressures. It's NOT. Although the relation (T2/T1)=(v1/v2)^(k-1)=(P2/P1)^((k-1)/k) holds true, end temperature is INDEPENDENT of throttling, etc. It does change due to leakage and heat transfer of a real compression process, that is neglected in isentropic (reversible, adiabatic) relations. Going back to the temperature independence of throttling, if P1 drops, P2 also drops accordingly only as a function of the volumetric compression ratio (v1/V2) raised by k. In a closed control volume, the compression ratio is a VOLUMETRIC parameter. Don't EVER use pressure ratios unless you're dealing with a turbine engine or you have specific pressure trace data or you'll look silly.
To the original poster: Your question is similar to that asked in the recent thread asking about maximum CR in a propane engine. The answer is that there is no single value nor range of values that can adequately cover every variable in a engine.
A factor that also comes into play are the objectives for the engine design. If the engine is to live almost exclusively at part load, and you want maximum fuel efficiency, there is an upper limit of compression ratio beyond which efficiency drops off again due to a multitude of factors like heat transfer (worsening ratio of combustion chamber surface area to volume); leakage through the rings; friction; increasing role of crevice volumes and quench zones; etc. For an engine developed for part load, this maximum compression ratio should be strived for, but again, there is no hard number, but from a theoretical derivation of a dual-combustion cycle with a defined peak pressure limit, thermal efficiencies cease to increase significantly past a (dynamic) CR of about 14:1. The point is that it's not constructive to raise the compression ratio simply for the sake of striving for the biggest number. However, if the emissions profile permits obviating a three-way catalyst, in addition to an optimally increased compression ratio, a small benefit in BSFC can be achieved by operating the engine slightly lean.
If the engine is to be run mostly at full-load and you are still concerned about fuel efficiency, you must balance increasing the compression ratio and timing advance with necessary fuel enrichment to prevent knocking. You might save far more fuel by running at a lower compression ratio and degree of spark advance, but maintaining roughly stoichiometric AFR, instead of running a higher CR and forced to enrich the mixture to a lambda of 0.8 that I've seen for some gasoline engines.
Running on E85, short of a major breakthough in engine efficiency (i.e. 45% increase), you will NEVER come out with a case of an engine that has the same or better mileage (read fuel consumption) on E85 as on gasoline, due to the approx. 45% shortfall in LHV. Run away from anyone who tries to convince you otherwise!!!