I looked for split and beam nuts. They look as if they would operate for a few dozen cycles, but are mostly proprietary and differ enough it's not easy to tell which would work for this application.
The best defense is a correctly designed threaded joint with sufficient elastic deformation that preload won't be lost in use. The main worry in any locking system is, if the fastener preload is insufficient that the locking element will retain the fastener and not leave an obvious clue that the fastener is no longer doing the job, leading, in some cases, to rapid fracture from fatigue.