Steppers are usually used where backlash is not terribly important, or is accounted for in the system design somehow, e.g. by seeking for the center of an interrupter slot that may be a few steps wide at the motor, or by using a bull gear or timing belt as the last pass, or by using a high gear ratio so that the stepper has to really scream to drive the system at max speed so backlash upstream of the last pass is reduced at the output shaft.
Running the motor in only one direction might help if your system has enough damping to minimize the stepper's natural ringing. Electronic damping in the drivers is sometimes used instead of or in addition to friction damping.
But the general answer to your question is 'no'.
Mike Halloran
Pembroke Pines, FL, USA