Powerhound, I think the hole is through the back wall of the front view, so it does seem to be at a nontraditional angle with respect to datums B and C.
Such a measurement can be done, but it really depends on the inspection method. Here's the basic concept: Somehow, on the drawing or in the CAD database, there is already a known angular relationship between the hole and the three mutually perpendicular datums. The GD&T simply constructs a .060 diameter imaginary cylinder around the perfect axis, and the actual axis must fall within that cylinder. So the tolerance sits at the same angle as the intended hole.
It sounds like you're asking for a breakdown in the direction or the datums (kind of like an x-y-z measurement report), and then you might be looking at sines and cosines and the Pythagorean Theorem (CMMs can do this pretty easily). Using these trig formulas you or the computer could determine the portion of the .060 diameter tolerance that applies in each direction.
John-Paul Belanger
Certified Sr. GD&T Professional
Geometric Learning Systems