sfsurfer: As I see this, there is a plexiglass enclosure 6'X 8' that has either walls with vent openings of no walls (other than support posts). The fan and top of the enclosure are 30" from the source of the fumes. Assuming the fumes are lighter than air and will, therefore rise, then the fan will pick them up and carry them through the duct. To determine the quantity of fumes to be exhaused you need to know the rate at which the fumes rise. This is not easy to determine. The fan flow rate can be determined from the maufacturer and corrected for duct and other losses. If you do not want the fumes to escape, and I assume you do not, then you will need to make sure that air is flowing into the enclosure on all sides; or vent openings are in the encloser sides.
What is this for? It sounds like a vapor extraction system of some sort. Are the fumes being directed somewhere or just dischaged to the atmosphere? It seems like soomething is missing?
Regards
Dave