It depends what you really mean with that question. If you want a script that finds all holes in your model and then prints out the center or creates reference points in it, then the answer is no.
If you want to select a hole and directly get the center coordinates or a reference point, then the answer is yes.
Some time a ago I've created for myself a plugin that does exactly this. Additionally a coupling can be automatically added between face region and reference point. But as mentioned, the user has to select the faces manually.
'let me know if you want to have the plugin.