Ice Station Zebra is a movie from 1968 with Rock Hudson and Ernest Borgnine. It is a name that I can easily remember and is rarely taken.
I concur with NickE on the semi frames. This also applies to at least some medium duty trucks. (I know the Chevy Topkick/GMC Kodiak for certain.) To be on the safe side I would assume that any frame that has all the crossmembers either bolted or riveted in place is heat treated.
While I agree that a "frame" is not a single part, any part that is welded already is highly unlikely to be heat treated as welding will locally re-heat treat the material. Now obviously whomever carries out modifications to a vehicle's frame or suspension parts must realize that a certain amount of risk goes along with such actions. (Just like everything else in life!)
As far as heat treating goes, you could do a Google search and find tons on info. But the 30 second story is that metals are crystalline lattice structures. The actual structure depends on the alloying elements used (carbon, manganese, chromium, vanadium, tungsten, etc.) and the cooling schedule. Different lattice structures have different mechanical properties. While you can't easily change the alloying of a piece of steel, you can reheat it and use a different cooling schedule - a.k.a "heat treating."
The material properties in the weld zone mainly depend on the material types of the two parts being joined, the filler metal, the flux/shielding gas used, and the cooling rate. Assuming the weld is properly sized the weakest area of the joint is usually directly adjacent to the weld - "the heat affected zone". This parent material has been heated by the welding process but relatively rapidly cooled due to the thermal mass of the parent part, often resulting in a more brittle material. (One reason the relatively slow TIG process can turn out higher quality joints is the slower heating/cooling.) Then adding to the problem weld joints are quite often is high stress areas.
ISZ