In a simple completion - tubing with a profile I would only run an XN.
as the need for more profiles in a more complex completion I would run multiple X nipples above the XN.
- example: 2 zone completion XN nipple, Packer, On/off c/w X profile, Pup joint, X nipple, 10 joints tbg, 1 blast joint, Sliding sleeve c/w X profile