Friends, the description in the question is misleading.
Making 2" NPT thread on 4" Blind flange is prohibited by ASME B16.5 (regardless to flange class)
Please see in Table 6 for reducing flanges, at columns 3+4: the smallest size of reducing outlet requiring Hub Flange for NPS 4" is 1.1/2"
As you all very well know, Blind Type Flange IS NOT Hub Flange, so, 2" outlet on 4" Blind is prohibited.
What you need here is: Threaded Reducing Flange 4"X2" #150 RF. As per ASME B16.5
It is hubbed flange, as it appears at bimr's post above.