There's scientific method, and there's cut-and-try, and there's a scale in between.
When you change something and it has an effect, do you understand WHY it had an effect?
In this day and age, no serious dyno testing should be done without instrumentation. The more, the merrier. Coolant temperature (possibly at multiple locations - not just at the waterpump or thermostat housing). Oil temperature (same). Oil pressure. Exhaust-gas temperature, preferably at each cylinder as close to the exhaust port as possible. Lambda, preferably for each cylinder. If you have the ability to measure real-time cylinder pressure, fantastic, that's a real help for optimising ignition timing. If it's sensitive enough, that can tell you if the intake is restrictive or the exhaust is restrictive or if pressure-wave effects are helping or hindering.
If you haven't the instrumentation, you're just guessing ... cut-and-try.
I've seen the shows like Engine Masters. The bits you see on youtube etc are the showy parts where it looks like they're doing something. They don't show the underlying design and mathematics and simulation that went into the design of the various bits and pieces that they're showing being tested on the dyno. The grunt work that really counts behind the scenes, is boring to watch.