You should base your cycle times and vacuum/pressure levels on the varnish manufacturer's recommendations and not the VPI tank manufacturer. Each varnish has specific qualities that require specific treatments. Also, I have heard that increased vacuum level or increased vacuum time may cause problems with some varnishes (de-polymerization?) but I cannot qualify that statement with facts or direct experience.
That being said, your specification should be based on establishing reliable varnish penetration for the different voltage coils that you handle (2300V, 4000V, 6600V) based on the different types and/or different layers of insulation that are required for each voltage. Treating sample coils, as described by motorwinder, is the only way to know that your process times are good.
That being said, keep in mind that 'sample coils' are typically placed in a fixture that clamps them between plates of steel (or some other hard impermeable substance) to simulate being installed in a stator slot.
Finally, I would agree with Motorwinder that the pressure cycle is more important to penetration than the vacuum cycle. However, that may be dependent on the varnish type that you are using. Again, I would say that the varnish manufacturer should be the definitive source for determining your cycle times.