I wouldn't make that automatic assumption. Oil drainage paths from the cylinder head, in particular, come to mind. If there is anything inside the engine that is dependent on splash lubrication, that could also be a problem. Anything that is reliant on oil draining back to the sump by gravity may require redesign. This is the case for a good many, if not all, turbochargers. Crankcase venting is another issue; the vent path had better allow oil to drain back rather than pool in the vent.