For things like diff housings I'd have said a wilely guy could make a cost effective sand casting for ones or tens off. I had a cast part made that cost, for a one off, less than the welded proto cost, including the pattern. The reason is that with a sandcasting you can make your pattern any old how, including basing it on an existing part. You'll have to include draft angles and allow for contraction, of course, but for a complex shape an existing part makes a great basis for the pattern. Talk to or work with the pattern maker at the foundry.
Commercial automotive components are more likely to be low pressure die cast. There is a slight improvement in porosity and shut lines, but if you can afford the time to remelt the failures, there is not a whole lot wrong with sandcast, as, in this case, stiffness is more important than strength. I'd say that in the case of wheels, where strength is more important, that I would be wary of sandcast parts.
Cheers
Greg Locock
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