Grizzly,
Most CO2 sensors use non-dispersive ifrared (NDIR) detection. From my own experience, these sensors are significantly affected by barometric pressure. NDIR sensors that I calibrated in Reno at 1,000 ppm all read 1,300-1,400 ppm when we got to Stockton, some reduced (3,000-4,000 ft) altitude later. Imagine what a 35,000 ft altitude plane ride does.
They need to be zeroed and spanned after installation - forget the factory calibration.
From there, I would recommend running a zero and approx. 1,000 span gas at least monthly through the sensors, adjusting the zero and span setscrews as needed.
Assuming you can maintain this type of regimen, CO2 sensor use can be effective for areas with intermittent, heavy occupancy. This includes classrooms, theaters, cafeterias, gyms, and auditoriums. I would not use CO2 control in high air exchange buildings such as labs and hospitals, because the levels wouldn't typically exceed 200-300 above ambient.
I hope some of this helps. Best regards, -CB