IJR - not to discount the other comments which were good...For years our firm and a previous firm I was with designed a multitude of cast-in-place concrete floors and roofs with no allowance for the flexibility of the supporting girders (i.e. - assumed that they were perfectly rigid). This was essentially the method used for many years by thousands of engineers before the advent of computers.
In many cases, for example, we would analyze a continuous run of a concrete pan joist supported by numerous supporting concrete girders. While I haven't done an exhaustive check considering the flexibility of the supporting girder and its effect on the moments and shears of the supported continuous joist, I would think it is a minimal effect, or, an effect that is more than accounted for by the load factors included in your design.
We have a lot of floors out there that have performed very well using this procedure.
As far as torsional effects go, the ACI code allows the designer to neglect torsional effects, or provide for a minimum torsional moment, if the system is not dependent upon the torsional restraint for safety. In other words, if you design you joist to be simply supported at the perimeter beam, then the perimeter beam doesn't need to torsionally resist the negative moment of the joist that it supports (see ACI 11.6.2.2)