Loads are the sum of (1) centrifugal force from rod big end, (2)inertia force from reciprocating parts, (3)pressure in combustion chamber acting on piston top. Loads vary in size and direction at every crank angle. However, there are two worst cases that can give you good results: maximum inertia force at high rpm and closed throttle, maximum gas load at low rpm (lugging) where there is minimal inertia load to offset it.
Having the force, you would next need to know the allowable unit loading (psi) of the bearing material, and that will give you bearing area. There are other things like l/d ratio, overlap between main and rod journals, stroke, and how much room you have in the crankcase. You don't want to make the journal so large that the rod bolts hit something.