If this is for a federal project, then FEMP-designated product standards are mandatory, as well as public law requiring life cycle cost analysis and usage of a 40-year life cycle cost analysis complying with NIST 135.
ASHRAE does point to specific system curves for optimizing the system, which for my interests is pretty much IPLV KW/TON. That will probably take at least a year of trending on condenser temperatures, tonnage, and KW/TON.
Following the FEMP-designated standards, when you go to large centrifugals, until the last years or so, only one vendor could meet the full and part loads required for federal procurement, and the FAR includes requirement of documentation of LCCA for optimal selection. I believe that is a major reason why you will find so many R-123 machines on federal projects. I had to address that issue20 years ago, still the same today.
No arcane matters, just LCCA and meet minimum FEMP-designated standards. As a federal employee who has just finished going through that process, I hope you are doing so now if working on a federal contract.
I don't agree with you on all points, DR, as the situation I was in (undersized constant primary/constant secondary plant, oversized AHU coils) differs from yours. I'm looking at about 30 central AHU's that are single fan, dual duct. The cold duct is sized for NFPA requirements, and the coils are sized for that flow (oveersized, unless we go to dual fan dual duct and carry the NFPA 92A requirements on the cold deck). The FAR requirements, however, are the same.
I've contracted out the hydronic calculations, as a drawback to being a federal engineer is we cannot (within a coule years) get software loaded. At that point, the LCCA will determine if we go variable primary or variable plus booster. Pump energy will drive that. If we go variable primary, then pressure independent control valves are needed to operate against variable pressure in order to meet temperature setpoints. For critical areas, such as OR's, we need to maintain both humidity and temperature. Might not be the situation you are facing. If conditions were always the same, HVAC could be made into a video game and we'd be replaced by teenagers.