For us Europeans, 10in water is equal to about 25mbar.
(Sorry, just thinking aloud!)
As others above say, typical maximum DIRTY pressure drop is about 50mbar - 20in. This is measured from the outlet flange of the turbo(s) to atmosphere.
The MWM engines I dealt with also has a minimum pressure, usually 30mbar.
With respect to all above, you have to start with the desired back pressure, say 45mbar, then design the exhaust system and specify the required clean (new) design back pressure for silencers, catalytic converter, heat recovery (if any), Exhaust runs, bends etc.
We always started with 15mbar total for silencer and cat (since we often bought then as a package). We then might have to adjust this once design has verified the complete exhaust.
As catserveng says, refer to the caterpillar application guide. The MWM one is on the MWM website. MWM.net - downloads - layout of power plant.
The CAT document I last saw two years ago, a good document, we always looked at other engine makers application guides, since they often overlap in their recommendations.