1. Whenever an LMC modifier follows the tolerance value, a physical virtual condition functional gage is not possible. You could work according to the "axis interpretation" (a tolerance zone for the axis including bonus tolerance when available), or make the CMM generate a virtually simulated virtual condition boundary inside the material, if possible.
2. Whenever an LMB modifier appears after the datum reference in the feature control frame, a physical datum feature simulator for this datum reference is not possible. You could virtually simulate a theoretical true geometric counterpart using the CMM. A physical fixture gage will not be used. If this is not possible or not desired, the LMB modifier could be disregarded at the expense of potentially rejecting some good parts when simulating the datum at RMB.
3. LMC and MMB can be combined, but for what purpose? Typically, LMC is combined with LMB when you want to provide allowance for additional variations as long as wall thickness between the datum feature and the controlled feature is maintained, or as long as there is some stock for subsequent machining operations is kept available. You combine MMC and MMB when you want to allow additional variations as long as parts assemble together at their worst case tolerance conditions.