You'd have to make a couple of assumptions about the connections in the structure, but in general, I would start with a free body diagram to understand the reactions in the system, followed by a shear and moment diagram, which will give you the shear and moments that you need to perform direct integration to get the deflection of the top beam at any given distance from a selected end (max. deflection would be where the moment is highest on the diagram). You would also have to determine your moment of inertia and modulus of elasticity based on the cross-section and material spec that you've provided.
To rb1957's point, it would help us help you if we understood where you were having trouble (don't know what to do, don't know what NOT to do, don't know HOW to do it, what considerations or assumptions need to be clarified or made, etc).
When you say "deflection of a frame" do you mean deflection of the top beam or the deflection of all members (including supports and braces)? This is just a starting point. You'd have to take into account anchorage, the eccentricity of the load, application of the frame, safety factor, end-fixity, etc.