In one simple scenario, the leak is taking away heat that would not otherwise escape. If it is considered just an isolated leak, and the plant does not have regenerative feedwater heating, the energy loss is = Mass Flowrate X (Enthalpy of Leak - Enthalpy of Feedwater entering the Economizer).
However things are generally much more complicated if the leak is spraying water on other heat transfer surfaces within the HRSG. Apart from the physical damage potential of the leak, it will tend to drastically reduce the heat absorption in adjacent economizer tubes which are being sprayed by the leak. Addressing this by analysis is very difficult.
You probably get a reasonably accurate indication of Heat Rate impacts by using station metering of fuel flow, depending on the calibration of your flowmeters.