If that question could be answered in 1 paragraph, it would put EPRI and 200 consultants out of business. A partial list is ( for a 500 MWe unit) :
-water chemistry issues, UDC under deposit corrosion, hydrogen damage
-operator error, maintaining fires when the unit has lo-lo water level
-incorrectly designed furnace waterwall , including circulation issues ( for drum type boilers)and thermal hydraulic sensitivity issues for supercritical units
-liquid phase coal ash corrosion of superheater and reheater tubes for high sulphur coal-fired units
-incorrect dissimilar metal weld design at the ferritic-to-austenitic transition in superheater and reheater tubes
-incorrect spray attemporator design or control method
-oxide scale buildup within ferritic reheater tubes onus units that do not have a steam to reheater bypass system
-creep and oxidation damage to ferritic tubes that are being overheated for various reasons
-graphitization of CS superheater tubes and headers upstream of the 1st spray attemporator
-cyclic operation of a boiler that was designed strictly for base load operation
"Whom the gods would destroy, they first make mad "