I would think it would depend on the size of the blower, and the size of the room or building it's in, and the airtightness or environmental factors in the room or building.
The air that goes through the blower has to come from somewhere. Where do YOU want it to come from? Consider whether or not people will be able to open or close the doors to the room where the blower is located, if it's running. I used to go into a pulp mill where the entrance to one maintenance shop was through the intake plenum for a bunch of ventilation fans. Some days, you could hardly open the door, and if you weren't careful, it would slam shut on you or your appendages if you let go of it.