With a 3-button mouse, you don't have much chance of doing much. I suggest you learn how to use keyboard shortcuts (AKA 'hot keys') if you're looking for a way of avoiding selecting menu items or toolbar icons. However, be warned, NX is a product that provides so much functionality that it's naive to think that you can actually be productive without having to deal with menus and toolbars.
John R. Baker, P.E.
Product 'Evangelist'
Product Engineering Software
Siemens PLM Software Inc.
Industry Sector
Cypress, CA