Usually, especially in hurricane regions, design wind speeds are accompanied by a large storm. NO ONE in their right mind leaves doors and windows open in a hurricane. Your question could easily apply to, say, french doors or a garage door on a house. If you leave the door open the storm comes in. Does that make any sense? You can engineer for whether doors and windows are designed to take wind loads. You cannot engineer for whether Gomer Stooge leaves the door open in a hurricane. It's kind of like legislating stupidity, you can't do it. Otherwise, if you really feel it needs to be pressed, design for the worst case of which you can think. If it makes you feel better put a note on your drawings stating that all doors must be closed during a design wind event.