wj33:
What you are describing is what is standardized domestic hot water heating for residences. And what is considered good practice is to allow for air separation at the highest points in the circuit - usually in the form of Tees, but acting as elbows with one flow-through connection pointed upwards and with an extended pipe nipple that is capped. This serves as an air chamber. Several of these are used in the circuit - always at the high spots. In fact, if you have a quality plumbing installation in your house, you probably have these installed in the piping.
The air chambers serve two purposes:
1) To isolate and separate any air or inerts in the circuit;
2) To serve as expansion chambers for the hot water as well as "shock absorbers" against water hammering or sudden shocks.
I've always considered the above to be good practice and have seen to it that my house has liberal air chambers in the hot water circuit.
Unless you have continuous input of air into the hot water, you don't have any need to expel or evacuate it. You say you have a closed circuit, so I would simply keep the air in the system, but with an air expansion tank or chamber at the highest point. The air content, when controlled in this fashion is actually useful and need not be vented.
Art Montemayor
Spring, TX