I'm surprised when I do get balanced currents particularly when the plant is not running.
If you had a 200 amp panel balancing would not help. If the panel is 400 amps or more, what's the problem?
You most likely have single phase loads that are not balanced. You may even have a local magnetic field that is affecting your tong meter more on one phase than the others.
If a lot of the lighting is turned off on the weekend, it's possible that the weekend lighting load is unbalanced.
A couple of single phase air conditioners in the offices, and/or the loads that jraef has suggested can be responsible.
You have a 49 Amp difference on a base current of 255 Amps. Thats about 19%. On Monday morning, much of the unbalance may go away. Even if it does not change you may be adding another 1000 Amps of balanced motor load. Now you're looking at a 49 Amp difference on a base current of 1255 Amps. That's less than 4% imbalance.
Unbalanced supply voltages can sometimes result in a disproportionate current unbalance.
When you're planning an installation, you strive for a balanced system. When you measure the currents at an industrial facility that is not operating, what you got is what you get. Is this overloading your main transformer bank?
What is important is first, the voltage balance when the panel is loaded.
Second, you should not draw more current on any one phase than your breakers conductors and transformers are rated at.
Third, heating in the conductors, or I^2 R losses. If one phase is loaded heavier than the others the heating losses will be a little more than if the currents are balanced. This is usually a small loss.
Check your currents when the plant is running. then check the voltages. If you have unequal voltages, check your motors for running hot. If nothing's hot and nothing's overloaded, don't fix it.
yours