For a recip / plunger pump, vaguely recall a thumb rule that the gap between max developed dp and dp gap from max op pressure to PSV setpoint should be at least 40%, in a well attenuated discharge line (probably triplex or more heads + pulsation dampener) to avoid accidental lifting of PSV due to pressure pulsations. And use a pilot op PSV or a bellows PSV to account for high dp in the PSV discharge line back to suction vessel.