More often (from a piping perspective) is is a very important matter of WHERE the deflection is and HOW MUCH deflection (bending) is expected. Drain points (constant downward slopes to a very specific point, vent points or vapor protection requires constant upward slopes to a different point, sewage or slurries require specific max and min slopes to move the entrained solids to the end of the pipe, etc.
The pipe itself and contents are usually very predictable loads. (Surge and water hammer unpredictable but massive loads.) Expansion and contraction require specific large geometric bends and straights and anchors, but it is drains and vents and cargo capacities transfers that force slope limits on the supports. And a pipe bridge is just an expensive support, as far as a pipist cares..