Deposition Quantification Methods?
Deposition Quantification Methods?
(OP)
Hi all,
Some background for the subsequent question.
We are working on a system for a targeted delivery of aerosolized drugs in to the lungs.
The general principle of how the system operates is by releasing a bolus of the aerosolized liquid infused with magnetic particles (Fe3O4 - magnetite) in to the respiratory tract, bringing it to a specific location and then using a magnet, the bolus is deposited.
Now we are trying to quantify the amount of deposition from the bolus, and to do so we have tried the next method:
Using regular table salt (NaCl) mixed in the solution of the liquid and the magnetic particles, to try and measure the increase in conductivity of DI water (after rinsing the deposition area with that DI water) compared to a base line sample of clean DI water.
So far we had inconsistent and seemingly random results.
To measure the conductivity we used this device.
So my question is basically if anyone have any ideas on how to measure the deposition, preferebly using substances that are "safe" (e.g. salt, magnetite, fluorescein...) and can be measured using "basic" equipment that can be found in a typical chemistry lab (we access to a medical center labs and in an academic institute).
Some background for the subsequent question.
We are working on a system for a targeted delivery of aerosolized drugs in to the lungs.
The general principle of how the system operates is by releasing a bolus of the aerosolized liquid infused with magnetic particles (Fe3O4 - magnetite) in to the respiratory tract, bringing it to a specific location and then using a magnet, the bolus is deposited.
Now we are trying to quantify the amount of deposition from the bolus, and to do so we have tried the next method:
Using regular table salt (NaCl) mixed in the solution of the liquid and the magnetic particles, to try and measure the increase in conductivity of DI water (after rinsing the deposition area with that DI water) compared to a base line sample of clean DI water.
So far we had inconsistent and seemingly random results.
To measure the conductivity we used this device.
So my question is basically if anyone have any ideas on how to measure the deposition, preferebly using substances that are "safe" (e.g. salt, magnetite, fluorescein...) and can be measured using "basic" equipment that can be found in a typical chemistry lab (we access to a medical center labs and in an academic institute).
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RE: Deposition Quantification Methods?
Is a measurement sensitivity of 0.01us/cm low enough to detect the quantities you are dealing with?
Regards
Ashtree
"Any water can be made potable if you filter it through enough money"
RE: Deposition Quantification Methods?
RE: Deposition Quantification Methods?
It has been tested before but with little to now success
We are already way past the proof of concept in an in-vitro experiments (we can target an area as small as 30mm in length by 5mm in width with an accuracy of less than 1mm)
We don't have to worry about agglomeration as we use particles coated with surfactant.
We do have around 95-99% of the bolus deposited at the desired location but we need to quantify the deposited amount for the article.
For now we want to try and quantify the deposition using the substances that are already in the bolus (i.e SPION's-Fe3O4 and salt-NaCl) or maybe use other bio-compatible chemicals such as Fluorescein.