You seem to have a qualitative understanding of what's going on. What you would do from there if you were a structural engineer would be to quantify all of that information. A diaphragm is pretty stiff and strong, but how stiff and how strong, and is it enough.
Let's say you come up with a given required diaphragm strength to support your building and stabilize it. If the material you want to use will not be able to supply that strength, you will have two choices: change to a stronger material or reduce the demand on the diaphragm. Adding additional walls or frames in the interior region of the building would serve to reduce the diaphragm's internal forces and potentially make a material work that wouldn't otherwise. The other option would be to switch to a stronger diaphragm material, such as a steel deck in stead of plywood, or to use a stronger connection, such as having blocking under all the plywood joints and lots and lots of extra nails.
Basically, wind load will hit a wall and travel to the roof diaphragm for the upper part of the wall, and to the slab or foundation directly for the lower portion of the wall. All of this load will then travel through the diaphragm to either a shear wall or a frame. Those in turn will carry the load to the ground. That's not to say there aren't alternate methods of designing your load path but it's probably cheaper than most if not all to build. Besides finding all of these forces and strengths, you also have to check how all of these components will cooperate with each other, and if they will actually behave as assumed. It's fine to assume, for instance, that a frame will share load evenly with a shear wall, but will it actually do so? These are some of the things we check, or should check when necessary.