Yes there is. As mentioned above, any noise that is induced in-to/on-to the + and - conductors of the loop will be eliminated in differential mode. With Single Ended inputs this noise level becomes part of the signal reading thus leading to signal error. One example of this at our plant is our 480 VAC Variable Frequency Drives. The electrical power conduits (aluminum) are mixed with control signal conduits. Some of these runs are over 300 feet long. Our flow and level measurement signals (4-20mA) have a high level of mixed frequency noise from these drives. Differential mode works well to minimize this noise problem. Although it is not 100% rejection, this mode works well enough for our application.
If you can use some type of industrial IP network between your instruments and your PLC, you can eliminate 99% of your noise problems in addition to having complete remote access to the instrument for monitoring failures, recalibrations and a wealth of other data.