A pressure relief system should be the last level of protection for equipment and personnel against hazards due to release of energy or fluids. You want it to work when all else has failed, including failure of personnel (as in failing to reopen a valve after it has been closed for maintenance) So using isolating valves in relief lines is not a good idea (although it can be done in with the right design and controls). However, a relief system should “operate” only under worst case situations,which hopefully never happen, so you should not be replacing rupture disks with any regularity – if at all (although depending upon pressure cycling etc, they may need to be replaced for PM, which should be infrequent if they were specified correctly.)
If you really think that overpressure could happen with some frequency, my impression is that you should be looking at other ways of limiting the maximum pressure of the pumps, which could be mechanical or instrumentation/control based. Without knowing anything about your pumping system, its hard to say what the options might be. It may very well be that these features/changes would eliminate the need for rupture disks (or relieve valves) altogether – but that depends on the type of features, and the consequences of overpressuring the pipe.
Also, those 10 inch disks seem awfully large. What kind of flow rate could you need to be relieving if you need a ten inch (or two ten inch) to relieve with a relieving pressure of (at least) 350 Psig discharging (I presume) to atmosphere?! How were those 10 inch sizes determined? Further, I don’t understand your reference to the surge device – that would have a completely different application then relieving pump flow.