Depends how they are actuated. Depends whether there is a single point of failure.
Cross-piloted PO checks are easy to install but are still actuated by the same directional valve ... which is a single point of failure.
Separate PO checks or rod locks actuated by an independent directional valve require two directional valves to actuate for the machine to move (provided that the system is properly arranged). If done in this manner, that independent directional valve would have to be monitored somehow to make sure it is changing state properly in both directions (not just a switch in the reset circuit - that alone won't prove that the monitoring switch is not shorted) because a failure of the pilot valve would not be self-revealing (the machine could still seem to be working normally).
This will not prove that there is not a piece of dirt stopping your PO check from sealing. This will not prove that your rod lock's friction surface is not worn out (I've seen it happen). PO checks cause stored pneumatic energy - even if someone switches off the air to the machine! - which can be a troublesome issue on its own account.
I'm interested in seeing what thoughts others have on this matter also. I have been finding that attempting to apply ISO 13849-1 to pneumatics in which you have to stop something from crashing down by gravity is a nightmare with no completely bulletproof magic solution. But the inability to achieve perfection is no excuse to do nothing. Just cutting solenoid power to one plain ordinary directional valve will provide no protection whatsoever against the spool failing to return.
A risk assessment should address whether mid-stroke stopping of the pneumatic function is a critical requirement. If the spool fails to return, the cylinder will carry through to the end of its stroke. If that's buried someplace deep in the machine with no normal operator access to it, maybe that's not an issue. If the full stroke of a short-stroke cylinder happens so quickly that there's no way someone could get to it in time, perhaps it's not an issue, either. But if the operator is inserting their hands into the tooling on every cycle to insert and remove parts in the fixture and it's big enough and accessible enough to be a hand-crusher ... ! ! !