EMD's have a positive displacement supply pump which shouldnt be affected much, but you may have to keep a close eye on your injectors to watch for a drop in the efficiency happening before the usual 8000 hours.
Just keep your lube oil in good condition and have it tested every month to look for drastic increases in metals which would indicate accelerated wear on your pistons, liners, and rings.
do good ring inspections to check for piston scuffing or high top ring clearance.