Liquid can build up even in a VERTICAL leg as a result of "vapour lock", assuming the gas is saturated at a temperautre above ambient temperature so that the impulse legs and transmitter act as a condenser. You need to make the legs, and the root valves on the pipe, larger in diameter and free draining so each line is free to drain all the way from the transmitter back into the pipe. The liquid and gas must be able to pass by one another in the cross-section of the impulse line and the valve to permit the liquid to freely drain back to the pipe below: if the cross-sections are too small, surface tension prevents the gas from passing by the liquid and the liquid becomes "vapour locked". Depending on the liquid, free draining is more or less guaranteed with 1/2" OD tubing impulse legs (assuming the valves are no smaller in inner diameter than the tubing), but is not guaranteed in either 1/4" or 3/8" OD tubing impulse legs.
This assumes also that the DP transmitter can handle the saturation temperature of condensate forming on its diaphragms, otherwise you need to trap some condensate in there to allow the trapped condensate to cool to protect the transmitter. That trapped liquid needs to be present when the transmitter is zeroed.