We have a part some 36" in diameter that is transfer molded using peroxide-cured epdm. We have considered a vacuum system, and may have to do so in the future. The biggest concern is how to port sufficient vacuum flow area, it will be a bit of a design challenge in the existing mold. Our vendor has other, smaller parts with vacuum systems for perfluoro-elastomers; the vacuum porting was designed into the molds from the start.