Data sheet accurarcy (datasheet Typ = 50uA but in reality it's closer to 75uA) or usefullness ("Average" current may be calculated on one, non-applicable use case) varies based on the complexity of the IC. For a simple logic gate, the data sheet is usually good enough. However, if you are talking about a multi-core processor, with several different modes of operation (sleep, wake, doze, etc), and hundreds of different use cases, then the data sheet may be less helpfull.
Finally, the validity of the data sheet numbers are directly related to the age of the design. In other words, early versions of IC (pre-production releases) may not always meet the final data sheet numbers.