Michie10-
As a general rule, air upstream of the fan should be given a one fan diameter distance so that a healthy velocity profile may develope (admittedly, most designs don't tolerate this rule of thumb due to space constraints). Likewise, before encountering obstructions, turns, or constrictions, there should a one fan diameter distance downstream of the fan for the same purpose. As for losses due to turns, constrictions, etc., I have found that unless your design is exceedingly simple, it is a fruitless exercise to try to obtain the static pressure curve with hand calculations. Normally a CFD program can be used but it really depends on how much you need to know. You can also send your prototype out for testing. There are many test labs that will provide you with the static pressure curve.
As indicated, full characterization of an air-cooled enclosure is no "walk in the park." You may want to get someone to help you who has done it before and validated their predictions by test.
Tunalover