Series A are larger with less, but larger studs, Series B is smaller with more studs.
From B16.47
Flange dimensions were based on the Manufacturers Standardization Society, Standard Practice (MSS SP) 44
flanges, except for Class 75 flanges that are ANSI/API 605 flanges.
At the request of the American Petroleum Institute (API), flange dimensions, in accordance with the API Standard 605,
were included in the subsequent drafts.
The API 605 flanges for Classes 150 and 300 and for sizes NPS 36 and smaller for classes higher than Class 300 are not
compatible with the MSS SP-44 flanges. [highlight #FCE94F]Thus, the MSS SP-44 flanges are designated as Series A flanges, and the API 605
flanges are designated as Series B flanges[/highlight] in this Standard. Materials covered in this Standard are as in ANSI B16.5, except
nickel base alloys are excluded. Pressure–temperature ratings are in accordance with ANSI B16.5.