Since an Inst relay will pickup with no intended time delay, it is not realistic to consider separation by a time interval. Obviously, the only separation possible is by current settings.
In general terms, the main point to remember is that you should try to avoid two devices tripping for the same fault by their Inst trips. This is done by limiting Main device Inst settings to the maximum fault value seen at the bus upon which they are located, or by not having Inst trips on the Main device at all.