Regardless of the orientaiton of the nozzle, the piping and support deigners should attempt to prevent any nozzle loading from occuring.
Doesn't happen (can't happen !!) in the real world with real budgets and real schedules, but one can dream.
I suspect, but cannot prove, that original poster was asking about nozzles that would create tangential flow, not radial flow, into the tank or PV. But such a nozzle would create even less stress than a radial nozzle because it intersects the tank with an ellipse, not a ring, and has more weld material to resist stress: so ... I'm puzzled.