A couple of things to think about. What is your VFD designed to do? Control flow or pressure. Depending on this, you may need to add a small slip stream back to the inlet on a PID control loop that helps maintain your desired parameters.
The calculation is fairly straight forward. You simply take the number of tubes and use this deterimine the average flow of CW through a single tube. Then, use the Bernouli equation to determine your pressure drop. For example if you have 100 gpm and 25 tubes, your average flow would be 4 gpm...
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I have converted several of my databases over from Excel to Access. Once you do it, you won't regret it. As ertan commented, you need to determine if your users are going to have read-only abilities or if everyone is capable of changing the database at once. You can actually open your excel...