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Does the sign matter when adding scale factor to response spectrum load cases in load combinations?

Does the sign matter when adding scale factor to response spectrum load cases in load combinations?

Does the sign matter when adding scale factor to response spectrum load cases in load combinations?

(OP)
When load cases are defined using a response spectrum analysis, does the sign of the scale factor matter when adding these to a load combination? I would say no, but what about the case when two response spectrums in different directions are being combined?

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