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O-ring based flange standard

O-ring based flange standard

O-ring based flange standard

(OP)
I'm looking for a flange standard to mate with stainless tube in a new process reactor.  The requirements are the following:

1)  An adopted standard i.e. various manufacturers make stuff for it.
2)  Works with medium pressures and medium vacuums (say 250 psig pressure, 1 millitorr vacuum).  
3)  Easy to assemble with reusable seals.  We currently use some conflat vacuum flanges.  The viton gaskets for these tend to be very tricky to assemble at larger sizes (6" tube and up), and the metal conflat gaskets are single use items.  I'd really prefer a spec that uses an O-ring in a groove.
4)  The flange OD is not excessively greater than the tube ID.  ANSI 150 lb flanges and the vacuum-world cousin of these, known as ASA, tend to be enormous.  A 6" tube takes an 11" flange, and a 2" tube takes a 6" flange.  
5)  Available in sizes for tube from 2" (or 1/2", even better) to 12" diameter.

I really want something that uses an O-ring groove, and I wouldn't have thought that was hard, but I can only find ASA flanges for this purpose.  They have the problem of giant flange OD versus tube OD.  

Thanks for any help.

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